COVID-19-associated coagulopathy

An ongoing global pandemic of viral pneumonia (coronavirus disease [COVID-19]), due to the virus SARS-CoV-2, has infected millions of people and remains a threat to many more. Most critically ill patients have respiratory failure and there is an international effort to understand mechanisms and predictors of disease severity. Coagulopathy, characterized by elevations in D-dimer and fibrin(ogen) degradation products (FDPs), is associated with critical illness and mortality in patients with COVID-19…

The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings

Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 in order to discuss and begin to understand neurological presentations in patients with suspected COVID-19-related neurological disorders…

High prevalence of deep vein thrombosis in mechanically ventilated COVID-19 patients

SARS-CoV-2 pneumonia patients present with coagulation disorders and marked susceptibility to thrombosis. However, the exact prevalence of DVT has been poorly investigated while the risk seems increased in ICU patients. Therefore, we decided to perform routine duplex ultrasound examination of the lower limb veins systematically, in order to administer appropriate anticoagulation in all intubated and mechanically ventilated patients with SARS-CoV-2 pneumonia…

Benefits, Open questions and Challenges of the use of Ultrasound in the COVID-19 pandemic era. The views of a panel of worldwide international experts

In the very last days of the year 2019a new virus of the coronavirus family, named Sars-Cov-2 was identified as responsible for the outbreak of cases of human pneumonia in Wuhan, China, a condition named Corona Virus Disease of 2019 (COVID-19). This virus displayed a rapid worldwide spread, with rates significantly higher and with much more severe clinical manifestations than those of seasonal influenza virus…

COVID-19: An executive report. April 2020 update

This Report does not intend to provide a comprehensive state-of-the-art review, but rather a snapshot of this rapid evolving situation, a field undergoing rapid evolution, with a daily flood of scientific publications and non-peer reviewed reports. The preparation of a COVID-19 report in this context is therefore a risky undertaking and the drafters of this document are well aware of their limits…

Preparing for the Next Pandemic

Annual influenza epidemics are like Minnesota winters — all are challenges, but some are worse than others. No matter how well we prepare, some blizzards take quite a toll. Each year, despite our ef- forts to increase the rates of influenza vaccination in our most vulnerable populations, unpredictable factors largely determine the burden of influenza disease and related deaths…