Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 (COVID-19)

Julien Nahum, Tristan Morichau-Beauchant, Fabrice Daviaud, Perrine Echegut, Jérôme Fichet, Jean-Michel Maillet, Stéphane Thierry


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) was identified as a new coronavirus causing pneumonia and acute respiratory distress syndrome. It has become a pandemic, spreading particularly quickly across Europe and the US. Most deaths are related to severe acute respiratory distress syndrome, but other organ failures, such as acute kidney failure and acute cardiac injury, seem also related to the disease. Inflammatory response is highly increased in coronavirus disease 2019 (COVID-19) infection, and inflammation is known to favor thrombosis. High dimerized plasmin fragment D (D-dimer) levels and procoagulant changes in coagulation pathways were reported among patients with severe COVID-19. An elevated rate of venous and arterial thrombotic events associated with COVID-19 infection has also been reported. This case series reports a systematic assessment of deep vein thrombosis among patients in an intensive care unit (ICU) in France with severe COVID-19.

JAMA Network Open.