SARS-CoV-2 Vaccines

Shortly after SARS-CoV emerged at the turn of the 21st century, the spike (S) protein (particularly in its prefusion [native] conformation) was identified as the immunodominant antigen of the virus. Evaluation of patients with SARS-CoV-2 revealed that binding and neutralizing antibodies primarily target the receptor-binding domain of the S1 subunit…

COVID-19 Guida Medica Clinico-Pratica FADOI

“Lontani, ma troppo vicini”. Questa in estrema sintesi la situazione che appena un mese fa sembrava toccarci solo marginalmente. Il vento della globalizzazione che ha rivoluzionato le nostre società con continui stravolgimenti, regalandoci in particolare la facilità di viaggiare annullando le distanze tra i diversi continenti, alla fine si è trasformato nella tempesta perfetta contro la nostra stessa Civiltà…

A living WHO guideline on drugs for covid-19

CLINICAL QUESTION What is the role of drug interventions in the treatment of patients with covid-19?
 NEW RECOMMENDATION
The latest version of this WHO living guidance focuses on remdesivir, following the 15 October 2020 preprint publication of results from the WHO SOLIDARITY trial. It contains a weak or conditional recommendation against the use of remdesivir in hospitalised patients with covid-19…

COVID Reference

Sei settimane dopo la terza edizione, il mondo è di nuovo cambiato. La pandemia infuria in Sud America, in particolare in Brasile, Ecuador e Perù. Il SARS-CoV-2 è sotto controllo in Cina, ma non in Iran…

The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings

Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 in order to discuss and begin to understand neurological presentations in patients with suspected COVID-19-related neurological disorders…

Benefits, Open questions and Challenges of the use of Ultrasound in the COVID-19 pandemic era. The views of a panel of worldwide international experts

In the very last days of the year 2019a new virus of the coronavirus family, named Sars-Cov-2 was identified as responsible for the outbreak of cases of human pneumonia in Wuhan, China, a condition named Corona Virus Disease of 2019 (COVID-19). This virus displayed a rapid worldwide spread, with rates significantly higher and with much more severe clinical manifestations than those of seasonal influenza virus…

COVID-19: An executive report. April 2020 update

This Report does not intend to provide a comprehensive state-of-the-art review, but rather a snapshot of this rapid evolving situation, a field undergoing rapid evolution, with a daily flood of scientific publications and non-peer reviewed reports. The preparation of a COVID-19 report in this context is therefore a risky undertaking and the drafters of this document are well aware of their limits…

Preparing for the Next Pandemic

Annual influenza epidemics are like Minnesota winters — all are challenges, but some are worse than others. No matter how well we prepare, some blizzards take quite a toll. Each year, despite our ef- forts to increase the rates of influenza vaccination in our most vulnerable populations, unpredictable factors largely determine the burden of influenza disease and related deaths…

COVID-19 e percorso diagnostico nel paziente

L’infezione da Sars-Cov-2 rappresenta una sfida senza precedenti per la medicina moderna. Gli sforzi fatti per comprendere le caratteristiche microbiologiche del virus e le misure messe in atto per ridurre il numero di contagi hanno portato ad un parziale contenimento della malattia a livello mondiale. In questo breve documento sono contenuti alcuni elementi per l’adeguata gestione del caso sospetto in ambiente ospedaliero e territoriale al fine di ottimizzare manovre di contenimento e gestione del paziente…

COVID-19: An executive report

At a time when Italy and all world is dramatically faced with the challenge of the SARS-Cov-2 infection, hitting many aspects of human civilization, Commissione Salute of the Accademia Nazionale dei Lincei felt that it is part of its social responsibility to provide the society at large with an Executive Summary of the current status of understanding of origin, pathogenesis, and treatment of COVID-19 pandemic…